The Catalans, led by the Argentinean star Lionel Messi put themselves in advantage thanks to two autogoles of the Italian box
First in the 38 minutes Daniele De Rossi shot his own goal trying to avoid a shot by the Argentinean attacker, and then the Greek Konstantinos Manolas unfortunately put the ball in In his bow with a rebound at 55 'after a shot from Samuel Umtiti who crashed into the wood.
Gerard Piqué would increase the advantage for the "culé" 59 'taking advantage of a ball that the goal Alisson left in the small area after manotear a shot of Luis Suárez, decreeing the transitory 3-0.
The outsiders would get the discount in the 80 'at the feet of Edin Dzeko which placed the ball in a corner of the goal defended by Marc-André Ter Stegen after receiving a great pass in the penalty spot.
However, four minutes from the end of regulation time the Uruguayan Suárez sentenced the win with a strong cross shot in the area.
Now, everything will be defined in the return duel next April 10 at the Olympic Stadium in Rome, where the Italians must make at least three goals to get excited about the move to the round of the four best teams of the tournament
FC Barcelona (4): Marc-André Ter Stegen; Nelson Semedo, Gerard Piqué, Jordi Alba, Samuel Umtiti; Ivan Rakitic, Sergio Busquets (66 'Paulinho), Andres Iniesta (84' Denis Suárez), Sergi Roberto (83 'André Gomes); Lionel Messi, Luis Suárez. DT: Ernesto Valverde.
AS Roma (1): Alisson; Bruno Peres, Federico Fazio, Kostas Manolas, Aleksander Kolarov; Kevin Strootman, Daniele De Rossi (77 'Gregoire Defrel), Lorenzo Pellegrini (60' Maxime Gonalons), Alessandro Florenzi (72 'Stephan El Shaarawy); Edin Dzeko, Diego Perotti. DT: Eusebio Di Francesco.
Goals: 1-0: 37 'Daniele De Rossi (Autogol) (BAR); 2-0 55 'Konstantinos Manolas (Autogol) (BAR); 3-0 59 'Gerard Piqué (BAR); 1-3: 79 'Edin Dzeko (ROM); 4-1: 86 'Luis Suárez (BAR)
Yellow: 43' Aleksander Kolarov; 85 'Kevin Strootman (ROM)
Referee: Danny Makkelie (HOL)
Stadium: Camp Nou